This is an outdated version published on 2024-03-01. Read the most recent version.

Effect of cardiovascular risk on SARS-CoV-2 RNA clearance in nasopharyngeal swabs from COVID-19 patients

e202403016

Authors

  • Daniela Mazzaccaro Unidad Operativa de Cirugía Vascular; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia.
  • Rosangela Piccinni Unidad Operativa de Medicina Interna; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia.
  • Valentina Milani Dirección Científica; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia.
  • Paolo Righini Unidad Operativa de Cirugía Vascular; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia.
  • Giovanni Nano Unidad Operativa de Cirugía Vascular; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia. / Departamento de Ciencias Biomédicas para la Salud; Universidad de Milán. Milán. Italia.
  • Giulia ML Gobbo Unidad Operativa de Medicina Interna; IRCCS Policlinico San Donato; San Donato Milanese. Milán. Italia.

Keywords:

SARS-CoV-2, COVID-19, Cardiovascular risk, RNA, Nasopharyngeal swabs

Abstract

We read with great interest the article by López-Pintor et al. (https://ojs.sanidad.gob.es/index.php/resp/article/view/323) on the relationship between the Cycle Threshold (CT) value of the initial polymerase chain reaction (PCR) of patients with COVID-19 and the persistence of infection.

Since late 2019, COVID-19 rapidly broke out around the world, causing a pandemic that has posed serious challenges to the medical community. To stop the spread of the virus, health officials have implemented a series of extraordinary Public Health measures, including quarantining people who have been exposed to COVID-19.

However, the optimal duration of quarantine remains a topic of debate, given findings regarding positive PCR test results for SARS-CoV-2 over many weeks. Therefore, identifying factors that predict negative tests could be useful in optimizing infection prevention and control measures, particularly in light of the current global effort to shorten the duration of isolation.

Downloads

Download data is not yet available.

References

López-Pintor JM, Herráez-Carrera Ó, Gaitán Pitera J, Sánchez-López J, Bautista-Serrano I, Arribas-Pérez F et al. Potencial utilidad del CT como marcador de persistencia de PCR positiva en pacientes con COVID-19 [Potential usefulness of CT as a marker of persistence of positive PCR in patients with COVID-19]. Rev Esp Salud Publica. 2022 Oct 26;96:e202210081. https://ojs.sanidad.gob.es/index.php/resp/article/view/323

Xu T, Chen C, Zhu Z, Cui M, Chen C, Dai H et al. Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19. Int J Infect Dis. 2020 Mar 14;94:68-71.

Joynt GM, Wu WK. Understanding COVID-19: what does viral RNA load really mean? Lancet Infect Dis. 2020. pii: S1473-3099(20)30237-1.

Qutub M, Aldabbagh Y, Mehdawi F, Alraddadi A, Alhomsy M, Alnahdi A et al. Duration of viable SARS-CoV-2 shedding from respiratory tract in different human hosts and its impact on isolation discontinuation polices revision; a narrative review. Clin Infect Pract. 2022 Jan;13:100140.

Hu X, Xing Y, Jia J, Ni W, Liang J, Zhao D et al. Factors associated with negative conversion of viral RNA in patients hospitalized with COVID-19. Sci Total Environ. 2020;728:138812.

Mazzaccaro D, Giacomazzi F, Giannetta M, Varriale A, Scaramuzzo R, Modafferi A et al. Non-Overt Coagulopathy in Non-ICU Patients with Mild to Moderate COVID-19 Pneumonia. J Clin Med. 2020; 9(6):1781.

Published

2024-03-01

Versions

How to Cite

1.
Mazzaccaro D, Piccinni R, Milani V, Righini P, Nano G, Gobbo GM. Effect of cardiovascular risk on SARS-CoV-2 RNA clearance in nasopharyngeal swabs from COVID-19 patients: e202403016. Rev Esp Salud Pública [Internet]. 2024 Mar. 1 [cited 2024 May 20];98:4 páginas. Available from: https://ojs.sanidad.gob.es/index.php/resp/article/view/324

Issue

Section

Cartas a la dirección

Categories