Evaluation of incidence and risk profile for suffering COVID-19 infection by underlying conditions among middle-aged and older adults in Tarragona

e202006065

Authors

  • Ángel Vila-Córcoles Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España. / Unitat de suport a la Recerca Tarragona-Reus. IDIAP Jordi Gol. Barcelona. España.
  • Olga Ochoa-Gondar Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España. / Unitat de suport a la Recerca Tarragona-Reus. IDIAP Jordi Gol. Barcelona. España.
  • Cristina Torrente-Fraga Departamento de Tecnologías de la información y la Comunicación. DAP Camp de Tarragona. Institut Català de la Salut. Tarragona. España.
  • Ángel Vila-Rovira Unitat de suport a la Recerca Tarragona-Reus. IDIAP Jordi Gol. Barcelona. España.
  • Eva Satué-Gracia Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España. / Unitat de suport a la Recerca Tarragona-Reus. IDIAP Jordi Gol. Barcelona. España.
  • Immaculada Hospital-Guardiola Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España.
  • Cinta de Diego-Cabanes Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España.
  • Frederic Gómez-Bertomeu Departamento de Microbiología. Hospital Universitari Joan XXIII. Institut Català de la Salut. Tarragona. España.
  • Josep Basora-Gallisà Servicio de Atención Primaria Camp de Tarragona. Institut Català de la Salut. Tarragona. España. / Unitat de suport a la Recerca Tarragona-Reus. IDIAP Jordi Gol. Barcelona. España.

Keywords:

COVID-19, Incidence, Risk, Comorbidity, Adult

Abstract

Background: Population-based data on the current COVID-19 pandemic is scarce. This study investigated incidence and risk to suffer COVID-19 by baseline underlying conditions in people ≥50 years in Tarragona region across march-april 2020.
Methods: Population-based retrospective cohort study involving 79,071 adults ≥50 years-old in Tarragona region (Southern Catalonia, Spain). Cohort characteristics (age, sex, residence, vaccinations history and comorbidities) were established at baseline, and Covid-19 cases occurring between 01/03/2020-30/04/2020 were registered. Cox regression analysis calculating Hazard ratios (HRs) adjusted by age, sex and comorbidities was used to estimate risk for COVID-19.
Results: Across study period, 1,547 cohort members were PCR tested (22.6% positive) and 367 were presumptive cases without PCR tested. Considering PCR-confirmed Covid-19, incidence (per 100,000 persons-period) was 441 overall (248, 141, 424, 1,303 and 3,135 in 50-59, 60-69, 70-79, 80-89 and ≥90 years-old, respectively; 380 in men and 497 in women; 259 in community-dwelling and 10,571 in nursing-home). By comorbidities, maximum incidence emerged among persons with neurological disease (2,723), atrial fibrillation (1,348), chronic renal failure (1,050), cardiac disease (856), respiratory disease (798) and diabetes (706). Lower incidence appeared in rheumatic diseases (230) and smokers (180). In multivariable analysis focused on community-dwelling individuals (N=77,671), only cardiac disease (HR: 1.47; 95% CI: 1.01-2.15; p=0.045) and respiratory disease (HR: 1.75; 95% CI: 1.00-3.02; p=0.051) were associated with an increased risk, whereas smoking (HR:0.43; 95% CI: 0.25-0.74; p=0.002) and influenza vaccinated (HR: 0.63; 95% CI: 0.43-0.92; p=0.015) appeared associated with a decreased risk.
Conclusions: Apart of increasing age and nursing-home residence, chronic respiratory and cardiac disease appear at increased risk for suffering COVID-19. This study investigated population-based incidence of COVID-19 infection by underlying conditions among adults ≥50 years in Tarragona (Southern Catalonia, Spain) across two first months pandemic period.

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References

World Health Organization. Coronavirus disease 2019 (COVID-19): situation report-87. April,16 2020. Disponible en: https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200416-sitrep-87-covid-19.pdf?sfvrsn=9523115a_2 [Consultado 17 Abril 2020].

Ministerio de Sanidad. Secretaría General de Sanidad y Consumo. Dirección General de Salud Pública, Calidad e Innovación. Centro de Coordinación de Alertas y Emergencias Sanitarias. Informe científico-técnico. Enfermedad por coronavirus, COVID-19. Actualización, 17 de abril 2020. Disponible en: https://pnsd.sanidad.gob.es/noticiasEventos/actualidad/2020_Coronavirus/pdf/20200421_INFORME_CIENTIFICO_SANIDAD_COVID-19.pdf [Consultado 6 Mayo 2020].

Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497-506.

Guan WJ, Ni ZY, Hu Y et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020;382:1708-1720.

Liang WH, Guan WJ, Li CC et al. Clinical characteristics and outcomes of hospitalised patients with COVID-19 treated in Hubei (epicenter) and outside Hubei (non-epicenter): A Nationwide Analysis of China. Eur Respir J. 2020: 2000562.

Grasselli G, Zangrillo A, Zanella A et al. Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy. JAMA. 2020;323(16):1574–81.

Zhou F, Yu T, Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395:1054-62.

Mizumoto K, Kagaya K, Zarebski A, Chowell G. Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020. Eurosurveillance 2020;25(10):2000180.

World Medical Association. WMA Declaration of Helsinki – Ethical Principles for Medical Research Involving Human Subjects. Disponible en: https://www.wma.net/policies-post/wma-declaration-of-helsinki-ethical-principles-for-medical-research-involving-human-subjects/. Consultado 14 Marzo 2020.

Vila-Corcoles A, Hospital-Guardiola I, Ochoa-Gondar O et al. Rationale and design of the CAPAMIS study: effectiveness of pneumococcal vaccination against community-acquired pneumonia, acute myocardial infarction and stroke. BMC Public Health. 2010;10:25.

Generalitat de Catalunya. Sub-direcció General de Vigilància i Resposta a Emergències de Salut Pública. Procediment d’actuació enfront de casos d’infecció pel nou coronavirus SARS-CoV-2. Disponible en: https://canalsalut.gencat.cat/web/.content/_A-Z/C/coronavirus-2019-ncov/material-divulgatiu/procediment-actuacio-coronavirus.pdf [Consultado 16 Abril 2020].

Lieberman JA, Pepper G, Naccache SN et al. Comparison of commercially available and laboratory developed assays for in vitro detection of sars-cov-2 in clinical laboratories. J Clin Microbiol. 2020:JCM.00821-20.

Hosmer DW, Lemeshow S. Applied Survival Analysis. Regression Modeling of Time to Event Data. New York: John Wiley & Sons, 1999.

Miyara M, Tubach F, Pourcher V et al. Low incidence of daily active tobacco smoking in patients with symptomatic COVID-19. Preprint v3. Disponible en: https://www.qeios.com/read/WPP19W.3 [Consultado 21 Abril 2020].

Lippi G, Henry BM. Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19). Eur J Intern Med. 2020;75:107-108.

Changeux JP, Amoura Z, Rey F, Miyara M. (2020). A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Disponible en: https://www.qeios.com/read/FXGQSB [Consultado 21 Abril 2020].

Cook TM. Hypertension is a clinically important risk factor for severe illness and mortality in COVID-19. Anaesthesia. 2020 Apr 27. Epub ahead of print.

Sattar N, McInnes IB, McMurray JJV. Obesity a risk factor for severe COVID-19 infection: Multiple potential mechanisms. Circulation. 2020. Epub ahead of print.

Lighter J, Phillips M, Hochman S, Sterling S, Johnson D, Francois F et al. Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission. Clin Infect Dis Off Publ Infect Dis Soc Am. 9 de abril de 2020.

Salem ML, El-Hennawy D. The possible beneficial adjuvant effect of influenza vaccine to minimize the severity of COVID-19. Med Hypotheses 2020;140:109752.

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Published

2020-06-26

How to Cite

1.
Vila-Córcoles Ángel, Ochoa-Gondar O, Torrente-Fraga C, Vila-Rovira Ángel, Satué-Gracia E, Hospital-Guardiola I, et al. Evaluation of incidence and risk profile for suffering COVID-19 infection by underlying conditions among middle-aged and older adults in Tarragona: e202006065. Rev Esp Salud Pública [Internet]. 2020 Jun. 26 [cited 2024 Nov. 24];94:15 páginas. Available from: https://ojs.sanidad.gob.es/index.php/resp/article/view/821

Issue

Vol. 94 (2020)

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Originales

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Copyright (c) 2020 Ángel Vila-Córcoles, Olga Ochoa-Gondar, Cristina Torrente-Fraga, Ángel Vila-Rovira, Eva Satué-Gracia, Immaculada Hospital-Guardiola, Cinta de Diego-Cabanes, Frederic Gómez-Bertomeu, Josep Basora-Gallisà

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