Comparison of Heart, Grace Scores and clinical parameters as predictors of cardiovascular events in patients with chest pain in the Emergency Department

e202312102

Authors

  • María Pérez Corral Servicio de Urgencias; Hospital Clínico Universitario Lozano Blesa. Zaragoza. España.
  • Pedro José Satústegui Dordá Facultad de Ciencias de la Salud; Universidad de Zaragoza. Zaragoza. España.
  • Eva Benito Ruiz Facultad de Ciencias de la Salud; Universidad de Zaragoza. Zaragoza. España. / Unidad de Cuidados Intensivos Pediátricos; Hospital Universitario Materno-Infantil Miguel Servet. Zaragoza. España.
  • Adrián Solans Atance Servicio de Urgencias; Hospital Clínico Universitario Lozano Blesa. Zaragoza. España.
  • Mª Teresa Fernández Rodrigo Facultad de Ciencias de la Salud; Universidad de Zaragoza. Zaragoza. España.

Keywords:

Chest pain, Emergency department, HEART score, GRACE score, Risk grade

Abstract

BACKGROUND // Risk assessment of patients with chest pain is based on clinical parameters; however, without a scoring system, such as risk stratification scales, estimates are less precise and accurate. The aim of this paper was to compare the HEART, GRACE score and clinical parameters in the prediction of major cardiovascular events (cardiovascular mortality or acute myocardial infarction) during hospitalization, in patients with chest pain attended in the emergency department.
METHODS // A descriptive observational study of patients with ischemic chest pain, who attended to the Miguel Servet University Hospital emergency department (Zaragoza, Spain) during one year was carried out. HEART and GRACE scores were calculated retrospectively from clinical history. Quantitative variables were expressed as mean (±standard deviation), and qualitative variables as frequencies and percentages. A bivariate analysis was carried out using the chi-square test. The performance of the scales and clinical parameters was compared by calculating the area under the curve. The primary outcome was the occurrence of a major cardiovascular event (cardiovascular mortality or acute myocardial infarction) during hospital admission.
RESULTS // 306 patients were registered (66.3% men, n=203), with a mean age of 71.45±12.85 years and a 48.7% history of ischemic heart disease. The areas under the curve for HEART scales, GRACE and clinical parameters were 0.80 (95% CI: 0.73-0.86), 0.79 (95% CI: 0.72-0.85) and 0.74 (95% CI: 0.68-0.80), respectively. During hospitalization, the incidence of the primary event was 13.4% and no low-risk patient, in both scales, presented a major cardiovascular event.
CONCLUSIONS // In patients with ischemic chest pain attended in the emergency department, the GRACE and HEART scale have a greater area under curve than clinical parameters.

Downloads

Download data is not yet available.

References

Bayón Fernández J, Alegría Ezquerra E, Bosch Genover X, Cabadés O’Callaghan A, Iglesias Gárriz I, Jiménez Nácher JJ et al. Chest pain units. Organization and protocol for the diagnosis of acute coronary syndromes. Rev Esp Cardiol Engl Ed. 2002;55(02):143-154.

Ramsay G, Podogrodzka M, McClure C, Fox KAA. Risk prediction in patients presenting with suspected cardiac pain: the GRACE and TIMI risk scores versus clinical evaluation. QJM. 17 de diciembre de 2006;100(1):11-18.

Sheps DS, Creed F, Clouse RE. Chest pain in patients with cardiac and noncardiac disease. Psychosom Med. 2004;66(6):861-867.

Eslick GD. Noncardiac chest pain: epidemiology, natural history, health care seeking, and quality of life. Gastroenterol Clin North Am. 2004;33(1):1-23.

Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR et al. 2014 AHA/ACC Guideline for the Management of Patients With Non-ST-Elevation Acute Coronary Syndromes: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 23 de diciembre de 2014;130(25):e344-426.

Than M, Cullen L, Reid CM, Lim SH, Aldous S, Ardagh MW et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study. Lancet Lond Engl. 26 de marzo de 2011;377(9771):1077-1084.

Amsterdam EA, Kirk JD, Bluemke DA, Diercks D, Farkouh ME, Garvey JL et al. Testing of low-risk patients presenting to the emergency department with chest pain: a scientific statement from the American Heart Association. Circulation. 26 de octubre de 2010;122(17):1756-1776.

Willems MNI, van de Wijngaart DJ, Bergman H, Adiyaman A, Telting D, Willems FF. Addition of heart score to high-sensitivity troponin T versus conventional troponin T in risk stratification of patients with chest pain at the coronary emergency rooms. Neth Heart J Mon J Neth Soc Cardiol Neth Heart Found. diciembre de 2014;22(12):552-556.

Ma CP, Wang X, Wang QS, Liu XL, He XN, Nie SP. A modified HEART risk score in chest pain patients with suspected non-ST-segment elevation acute coronary syndrome. J Geriatr Cardiol JGC. enero de 2016;13(1):64-69.

Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F et al. 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 14 de enero de 2016;37(3):267-315.

GRACE Investigators. Rationale and design of the GRACE (Global Registry of Acute Coronary Events) Project: a multinational registry of patients hospitalized with acute coronary syndromes. Am Heart J. febrero de 2001;141(2):190-199.

Steg PG, FitzGerald G, Fox KAA. Risk stratification in non-ST-segment elevation acute coronary syndromes: troponin alone is not enough. Am J Med. febrero de 2009;122(2):107-108.

Six AJ, Cullen L, Backus BE, Greenslade J, Parsonage W, Aldous S et al. The HEART Score for the Assessment of Patients With Chest Pain in the Emergency Department: A Multinational Validation Study. Crit Pathw Cardiol J Evid-Based Med. septiembre de 2013;12(3):121-126.

Backus BE, Six AJ, Kelder JC, Bosschaert MAR, Mast EG, Mosterd A et al. A prospective validation of the HEART score for chest pain patients at the emergency department. Int J Cardiol. 2013;168(3):2153-2158.

Mahler SA, Riley RF, Hiestand BC, Russell GB, Hoekstra JW, Lefebvre CW et al. The HEART Pathway randomized trial: identifying emergency department patients with acute chest pain for early discharge. Circ Cardiovasc Qual Outcomes. marzo de 2015;8(2):195-203.

Sakamoto JT, Liu N, Koh ZX, Fung NXJ, Heldeweg MLA, Ng JCJ et al. Comparing HEART, TIMI, and GRACE scores for prediction of 30-day major adverse cardiac events in high acuity chest pain patients in the emergency department. Int J Cardiol. 15 de octubre de 2016;221:759-764.

Moran AE, Oliver JT, Mirzaie M, Forouzanfar MH, Chilov M, Anderson L et al. Assessing the Global Burden of Ischemic Heart Disease: Part 1: Methods for a Systematic Review of the Global Epidemiology of Ischemic Heart Disease in 1990 and 2010. Glob Heart. 1 de diciembre de 2012;7(4):315-329.

Six A, Backus B, Kelder J. Chest pain in the emergency room: value of the HEART score. Neth Heart J. junio de 2008;16(6):191-196.

Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 14 de enero de 2019;40(3):237-269.

Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 07 de 2018;39(2):119-177.

Collet JP, Thiele H, Barbato E, Barthélémy O, Bauersachs J, Bhatt DL et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Eur Heart J. 7 de abril de 2021;42(14):1289-1367.

Huang Z, Wang K, Yang D, Gu Q, Wei Q, Yang Z et al. The predictive value of the HEART and GRACE scores for major adverse cardiac events in patients with acute chest pain. Intern Emerg Med. enero de 2021;16(1):193-200.

Leite L, Baptista R, Leitão J, Cochicho J, Breda F, Elvas L et al. Chest pain in the emergency department: risk stratification with Manchester triage system and HEART score. BMC Cardiovasc Disord [Internet]. diciembre de 2015 [consultado 23 de mayo de 2017];15(1). Disponible en: http://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-015-0049-6

Abu-Assi E, Gracía-Acuña JM, Ferreira-González I, Peña-Gil C, Gayoso-Diz P, González-Juanatey JR. Evaluating the Performance of the Can Rapid Risk Stratification of Unstable Angina Patients Suppress Adverse Outcomes With Early Implementation of the ACC/AHA Guidelines (CRUSADE) bleeding score in a contemporary Spanish cohort of patients with non-ST-segment elevation acute myocardial infarction. Circulation. 8 de junio de 2010;121(22):2419-2426.

Lev EI, Kornowski R, Vaknin-Assa H, Porter A, Teplitsky I, Ben-Dor I et al. Comparison of the predictive value of four different risk scores for outcomes of patients with ST-elevation acute myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 1 de julio de 2008;102(1):6-11.

Rathore SS, Weinfurt KP, Foody JM, Krumholz HM. Performance of the Thrombolysis in Myocardial Infarction (TIMI) ST-elevation myocardial infarction risk score in a national cohort of elderly patients. Am Heart J. septiembre de 2005;150(3):402-410.

Tscherny K, Kienbacher C, Fuhrmann V, Van Tulder R, Schreiber W, Herkner H et al. Risk stratification in acute coronary syndrome: Evaluation of the GRACE and CRUSADE scores in the setting of a tertiary care centre. Int J Clin Pract. 30 de octubre de 2019;

Sénior JM, Fernández A, Rodríguez A, Muñoz E, Díaz J, Gándara J et al. Validación y comparación de los puntajes TIMI y GRACE en pacientes con síndrome coronario agudo sin elevación del segmento ST. Rev Colomb Cardiol. noviembre de 2016;23(6):479-486.

Granger CB, Goldberg RJ, Dabbous O, Pieper KS, Eagle KA, Cannon CP et al. Predictors of hospital mortality in the global registry of acute coronary events. Arch Intern Med. 27 de octubre de 2003;163(19):2345-2353.

Than M, Herbert M, Flaws D, Cullen L, Hess E, Hollander JE et al. What is an acceptable risk of major adverse cardiac event in chest pain patients soon after discharge from the Emergency Department?: a clinical survey. Int J Cardiol. 1 de julio de 2013;166(3):752-754.

Kline JA, Johnson CL, Pollack CV, Diercks DB, Hollander JE, Newgard CD et al. Pretest probability assessment derived from attribute matching. BMC Med Inform Decis Mak. 11 de agosto de 2005;5:26.

Reaney PDW, Elliott HI, Noman A, Cooper JG. Risk stratifying chest pain patients in the emergency department using HEART, GRACE and TIMI scores, with a single contemporary troponin result, to predict major adverse cardiac events. Emerg Med J EMJ. julio de 2018;35(7):420-427.

Poldervaart JM, Langedijk M, Backus BE, Dekker IMC, Six AJ, Doevendans PA et al. Comparison of the GRACE, HEART and TIMI score to predict major adverse cardiac events in chest pain patients at the emergency department. Int J Cardiol. 15 de enero de 2017;227:656-661.

Cullen L, Greenslade J, Hammett CJ, Brown AFT, Chew DP, Bilesky J et al. Comparison of Three Risk Stratification Rules for Predicting Patients With Acute Coronary Syndrome Presenting to an Australian Emergency Department. Heart Lung Circ. octubre de 2013;22(10):844-851.

Mahler SA, Hiestand BC, Goff DC, Hoekstra JW, Miller CD. Can the HEART score safely reduce stress testing and cardiac imaging in patients at low risk for major adverse cardiac events? Crit Pathw Cardiol. septiembre de 2011;10(3):128-133.

Published

2023-12-01

How to Cite

1.
Pérez Corral M, Satústegui Dordá PJ, Benito Ruiz E, Solans Atance A, Fernández Rodrigo MT. Comparison of Heart, Grace Scores and clinical parameters as predictors of cardiovascular events in patients with chest pain in the Emergency Department: e202312102. Rev Esp Salud Pública [Internet]. 2023 Dec. 1 [cited 2026 Apr. 1];97:11 páginas. Available from: https://ojs.sanidad.gob.es/index.php/resp/article/view/185

Issue

Section

Originales

Categories

Most read articles by the same author(s)