Presence of SARS-CoV-2 RNA in semen

perspectivas7_garciasanmiguel

Authors

  • Lucía García San Miguel Centro de Coordinación de Alertas y Emergencias Sanitarias (CCAES). Ministerio de Sanidad. Madrid.

Keywords:

RNA virus, SARS-CoV-2, Semen

Abstract

In 2003, the presence of orchitis was observed in men infected with SARS-CoV. Since other viruses are shed in semen for long periods, there has been speculation that SARS-CoV-2 could follow the same shedding route and potentially be transmitted sexually, as well as damaging sperm and causing infertility. On the other hand, it is known that the virus entry receptor into cells (ACE2) is also found in testicular cells and that transmembrane serine protease 2 (TMPRSS2), mediator of virus entry through the receptor, is expressed in prostate epithelial cells. For this reason, SARS-CoV-2 has been searched for in semen and the manifestations at the testicular level have been studied, without, in general, neither one nor the other having been found.

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References

Cardona Maya WD. SARS-CoV-2 and the Testis: Similarity With Other Viruses and Routes of Infection [Internet]. Reproductive biomedicine online. 2020 [citado 24 de junio de 2020]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32362571/?from_single_result=SARS-CoV-2+and+the+Testis%3A+Similarity+With+Other+Viruses+and+Routes+of+Infection.

Perry MJ, Arrington S, Neumann LM, Carrell D, Mores CN. It is currently unknown whether SARS-CoV-2 is viable in semen or whether COVID-19 damages spermatozoa. Andrology [Internet]. 14 de junio de 2020 [citado 24 de junio de 2020]; Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300609/.

Pan F, Xiao X, Guo J, Song Y, Li H, Patel DP et al. No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019. Fertil Steril [Internet]. junio de 2020 [citado 24 de junio de 2020];113(6):1135-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164916/.

Paoli D, Pallotti F, Colangelo S, Basilico F, Mazzuti L, Turriziani O et al. Study of SARS-CoV-2 in semen and urine samples of a volunteer with positive naso-pharyngeal swab. J Endocrinol Invest [Internet]. 23 de abril de 2020 [citado 24 de junio de 2020];1-4. Disponible en:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179792/.

Li D, Jin M, Bao P, Zhao W, Zhang S. Clinical Characteristics and Results of Semen Tests Among Men With Coronavirus Disease 2019. JAMA Netw Open [Internet]. 7 de mayo de 2020 [citado 24 de junio de 2020];3(5). Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206502/.

Salam AP, Horby PW. The Breadth of Viruses in Human Semen. Emerg Infect Dis [Internet]. noviembre de 2017 [citado 24 de junio de 2020];23(11):1922-4. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652425/.

Li N, Wang T, Han D. Structural, cellular and molecular aspects of immune privilege in the testis. Front Immunol [Internet]. 11 de junio de 2012 [citado 24 de junio de 2020];3. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3371599/.

Published

2020-06-25

How to Cite

1.
García San Miguel L. Presence of SARS-CoV-2 RNA in semen: perspectivas7_garciasanmiguel. Rev Esp Salud Pública [Internet]. 2020 Jun. 25 [cited 2025 Feb. 15];94:2 páginas. Available from: https://ojs.sanidad.gob.es/index.php/resp/article/view/1092

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