New drugs and regimens for resistant tuberculosis
e202006066
Keywords:
Medications, Resistant tuberculosisAbstract
The authors reviewed with great interest the World Health Organization (WHO) guidelines for the treatment of multidrug-resistant tuberculosis (MDR-TB), updated in March and December 2019. Treatment regimens for tuberculosis sensitive to first-line drugs have been used with little modification since their establishment in the 60s and 70s of the last century. In 2016, in the WHO Europe region (comprising 54 countries), treatment was successful in 77.2% of all tuberculosis cases but only 57.2% of MDR-TB cases. . In recent years, the disease caused by Mycobacterium tuberculosis resistant to the most important drugs, rifampin and isoniazid, has become a growing global public health problem. It is estimated that 3.4% of new tuberculosis cases and 18% of previously treated cases are diagnosed with MDR-TB. There are a significant number of factors that explain the current epidemic of resistant tuberculosis, although the inappropriate or incomplete use of treatments is one of the main ones.
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WHO. WHO consolidated guidelines on drug-resistant tuberculosis treatment. Geneva World Heal Organ Licence CC BY-NC-SA 30 IGO. 2019.
WHO | Rapid Communication: Key changes to the treatment of drug-resistant tuberculosis. Geneva World Heal Organ Licence CC BY-NC-SA 30 IGO. 2019.
WHO Regional Office for Europe/European Centre for Disease Prevention and Control. Tuberculosis surveillance and monitoring in Europe 2019- 2017 data. Copenhagen WHO Reg Off Eur. 2019.
Global Tuberculosis Report 2019. Geneva World Heal Organ. 2019.
Monedero I, Caminero JA. Common errors in multidrug-resistant tuberculosis management. Expert Rev Respir Med. 2013;(8):15–23.
Guidelines for the programmatic management of drug-resistant tuberculosis: [emergency update 2008]. Geneva World Heal Organ. 2008;247.
Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M et al. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017;5(4):291–360.
Van Deun A, Maug AKJ, Salim MAH, Das PK, Sarker MR, Daru P et al. Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis. Am J Respir Crit Care Med. 2010;182(5):684–92.
Trébucq A, Decroo T, Van Deun A, Piubello A, Chiang CY, Koura KG et al. Short-Course Regimen for Multidrug-Resistant Tuberculosis: A Decade of Evidence. J Clin Med. 2019;9(1):55.
Ahmad N, Ahuja SD, Akkerman OW, Alffenaar JWC, Anderson LF, Baghaei P et al. Treatment correlates of successful outcomes in pulmonary multidrug-resistant tuberculosis: an individual patient data meta-analysis. Lancet. 2018;392(10150):821–34.
Monedero I, Bhavaraju R, Mendoza-Ticona A, Sánchez-Montalvá A. The paradigm shift to end tuberculosis. Are we ready to assume the changes? Expert Rev Respir Med. 2017 Jul 3;11(7):565–79.
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Copyright (c) 2020 Juan Espinosa Pereiro, Ignacio Monedero Recuero, Adrián Sánchez Montalvá

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